Publications

  • Selected Image Processing Publications and Patents

  • Selected Image Processing Publications and Patents

  • Selected Image Processing Publications and Patents

  • Newby, D.E., et al., Coronary CT Angiography and 5-Year Risk of Myocardial Infarction. N Engl J Med, 2018. 379(10): p. 924-933.

    Quantitative Imaging Biomarker Publications

  • Selected Biophysics Publications

  • Selected Image Processing Publications and Patents

  • Selected Image Processing Publications and Patents

  • Antoniadis, et al., Foretelling plaque disruption: Is the journey to Ithaca reaching destination? Atherosclerosis 244 (January 2016) 147-148.

    Selected Biophysics Publications

  • Buckler AJ, et al., Classification of Biological Tissue by Multi-Mode Data Registration, Segmentation, and Characterization. US Patent 9,235,887, issued January 12, 2016 (file date January 2013).

    Selected Image Processing Publications and Patents

  • Obuchowski NA, Buckler AJ, et al., Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims, Volume 23, Issue 4, April 2016, Pages 496–506, Academic Radiology.

    Quantitative Imaging Biomarker Publications

  • Ma X, Siegelman J, Paik DS, Mulshine JL, St Pierre S, Buckler AJ. Volumes Learned: It Takes More Than Size to “Size Up” Pulmonary Lesions. 2016 Sep;23(9):1190-8. Epub 2016 Jun 7. Review. Academic Radiology PMID: 27287713

    Selected Biophysics Publications

  • Selected Biophysics Publications

  • Selected Biophysics Publications

  • Buckler AJ, et al., (QIBA working group), Inter-Method Performance Study of Tumor Volumetry Assessment on Computed Tomography Test-Retest Data, Volume 22, Issue 11, November 2015, Pages 1393–1408, Academic Radiology.

    Quantitative Imaging Biomarker Publications

  • Motoyama, S., et al., Plaque characterization by coronary computed
    tomography angiography and the likelihood of acute coronary events in
    mid-term follow-up
    Journal of the American College of Cardiology, 2015.
    66(4): p. 337-346.

    Quantitative Imaging Biomarker Publications

  • Mulshine JL, Gierada DS, Armato SG III, Avila R, Yankelevitz D, Kazerooni EA, McNitt-Gray MF, Buckler AJ, Sullivan DC, Role of the Quantitative Imaging Biomarker Alliance in Optimizing CT for the Evaluation of Lung Cancer Screen-Detected Nodules, Journal of the American College of Radiology, Volume 12, Number 4, April 2015.

    Quantitative Imaging Biomarker Publications

  • McNitt-Gray MF, Kim GH, Zhao B, Schwartz LH, Clunie D, Cohen KB, Petrick N, Fenimore C, Lu JZQ, Buckler AJ, Determining the Variability of Lesion Size Measurements from CT Patient Datasets Acquired Under “No Change” Conditions, Translational Oncology, Volume 8, Issue 1, p. 55-64, February 2015.

    Quantitative Imaging Biomarker Publications

  • Selected Biophysics Publications

  • Ahmadi, A., A. Kini, and J. Narula, Discordance between ischemia and stenosis, or PINSS and NIPSS: are we ready for new vocabulary2015, JACC: Cardiovascular Imaging.

    Selected Biophysics Publications

  • Wan T, Madabhushi A, Phinikaridou A, Hamilton JA, Hua N, Pham T, Danagoulian J, Kleiman R, Buckler A. Spatio-temporal texture (SpTeT) for distinguishing vulnerable from stable atherosclerotic plaque on dynamic contrast enhancement (DCE) MRI in a rabbit modelMedical Physics 41, 042303 (2014);

    Selected Image Processing Publications and Patents

  • Keith JC, Buckler AJ, Hamilton JA, Development of vascuCAP™, an MR Image Analysis System for Longitudinal Surveillance of Cardiovascular Disease in Women Who Developed Preeclampsia. Hypertension in Pregnancy Congress, New Orleans, LA October 26-29, 2014.

    Selected Image Processing Publications and Patents

  • Buckler AJ, Keith JC, Advanced Biomarkers. European Biopharmaceutical Review. January 2014: p. 10-14.

    Quantitative Imaging Biomarker Publications

  • Huang EP, …, Buckler AJ, et al., Meta-Analysis Working Group, Meta-analysis of the technical performance of an imaging procedure: Guidelines and statistical methodology. Statistical Methods in Medical Research May 2014.

    Quantitative Imaging Biomarker Publications

  • Obuchowski NA, Barnhart HX, Buckler AJ, et al.,Statistical issues in the comparison of quantitative imaging biomarker algorithms using pulmonary nodule volume as an example. Statistical Methods in Medical Research June 2014.

    Quantitative Imaging Biomarker Publications

  • Kessler LG, Barnhart HX, Buckler AJ, et al., The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions. Statistical Methods in Medical Research June 2014.

    Quantitative Imaging Biomarker Publications

  • Keith JC, Buckler AJ, Hamilton JA, Development of vascuCAP™, an MR Image Analysis System for Longitudinal Surveillance of Cardiovascular Disease in Women Who Developed Preeclampsia, at Hypertension in Pregnancy Congress, New Orleans, LA October 26-29, 2014.

    Quantitative Imaging Biomarker Publications

  • Kessler L, Buckler AJ, et. Al., The Emerging Science of Quantitative Imaging Biomarkers: Terminology and Definitions for Scientific Studies and for Regulatory Submissions, June 2014.

    Quantitative Imaging Biomarker Publications

  • Obuchowski NA, …, Buckler AJ, et al.,Quantitative imaging biomarkers: A review of statistical methods for computer algorithm comparisons. Statistical Methods in Medical Research June 2014.

    Quantitative Imaging Biomarker Publications

  • Quantitative Imaging Biomarker Publications

  • Keith, J.J., A. Buckler, and J. Hamilton, Development of vascuCAP, an MR Image analysis system for longitudinal surveillance of cardiovascular disease in women who developed preclampsia. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health, 2014. 4(4).

    Selected Image Processing Publications and Patents

  • Buckler, A.J. and J.C. Keith, Advanced Biomarkers. European Biopharmaceutical Review, 2014: p. 10-14.

    Selected Image Processing Publications and Patents

  • Selected Biophysics Publications

  • Savarese G, Gotto AM Jr, Paolillo S, D’Amore C, Losco T, Musella F, Scala O, Marciano C, Ruggiero D, Marsico F, De Luca G, Trimarco B, Perrone-Filardi P. Benefits Of Statins In Elderly Subjects Without Established Cardiovascular Disease. A Meta-AnalysisJ Am Coll Cardiol. 2013 Aug 14.

    Selected Biophysics Publications

  • Gotto AM Jr, Moon JE. Pharmacotherapies for lipid modification: beyond the statinsNat Rev Cardiol. 2013 Aug 20.

    Selected Biophysics Publications

  • Boekholdt SM, Arsenault BJ, Hovingh GK, Mora S, Pedersen TR, Larosa JC, Welch KM, Amarenco P, Demicco DA, Tonkin AM, Sullivan DR, Kirby A, Colhoun HM, HitmanGA, Betteridge DJ, Durrington PN, Clearfield MB, Downs JR, Gotto AM Jr, Ridker PM, Kastelein JJ. Levels and Changes of HDL Cholesterol and Apolipoprotein A-I inRelation to Risk of Cardiovascular Events among Statin-Treated Patients: A Meta-Analysis. Circulation. 2013 Aug 21.

    Selected Biophysics Publications

  • Phinikaridou A, PhD, Hua N, PhD, Pham T, BSc, Hamilton JA, PhD. Regions of Low Endothelial Shear Stress Colocalize With Positive Vascular Remodeling and Atherosclerotic Plaque DisruptionCirculation: Cardiovascular Imaging. 2013; 6: p. 302-310.

    Selected Biophysics Publications

  • Buckler AJ, D.J., Wan T, Phinikaridou A, Kleiman R, Hua N, Hamilton JA, Madabhushi A, Keith JC, Non-invasive Theranostic to Predict and Assess Response to Atherosclerotic Drugsin Experimental Biology 2013: Boston.

    Selected Image Processing Publications and Patents

  • Thomas DG, Gaheen S, Harper SL, Fritts M, Klaessig F, Hahn-Dantona E, Paik DS, Pan S, Stafford G, Freund ET, Klemm J, Baker NA. ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format. BMC Biotechnology, 2013; 13:2.

    Selected Image Processing Publications and Patents

  • Nwabugwu C, Rakhra K, Felsher DW, Paik DS. In Vivo Imaging-based Mathematical Modeling Techniques that Enhance the Understanding of Oncogene Addiction in Relation to Tumor Growth. Computational and Mathematical Methods in Medicine, 2013; 2013(802512):1-8.

    Selected Image Processing Publications and Patents

  • Habte F, Budhiraja S, Keren S, Doyle TC, Levin CS, Paik DS. In situ Study of the Impact of Inter- and Intra-reader Variability on Region of Interest (ROI) Analysis in Preclinical Molecular Imaging. American Journal of Nuclear Medicine and Molecular Imaging, 2013; 3(2):175-181.

    Selected Image Processing Publications and Patents

  • Henningsson M, Botnar RM. Advanced respiratory motion compensation for coronary MR angiography. Sensors (Basel). 2013 May 24;13(6):6882-99.

    Selected Image Processing Publications and Patents

  • Makowski MR, Henningsson M, Spuentrup E, Kim WY, Maintz D, Manning WJ, Botnar RM. Characterization of Coronary Atherosclerosis by Magnetic Resonance Imaging. Circulation. 2013 Sep 10;128(11):1244-1255.

    Selected Image Processing Publications and Patents

  • Habte F, Ren G, Doyle TC, Liu H, Cheng Z, Paik DS. Impact of a Multiple Mice Holder on Quantitation of High-Throughput microPET Imaging with and without CT Attenuation Correction. Journal of Molecular Imaging and Biology, 2013; 15(5):569-75.

    Selected Image Processing Publications and Patents

  • Makowski MR, Botnar RM. MR Imaging of the Arterial Vessel Wall: Molecular Imaging from Bench to Bedside. Radiology. 2013 Oct; 269(1):34-51.

    Selected Image Processing Publications and Patents

  • Buckler AJ, et al., Classification of Multi-Mode Data Registration, Segmentation, and Characterization. US PTO 13/732,674 Pending, January 2013

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Paik D, Ouellette M, Danagoulian J, Wernsing G, Suzek B, A Novel Knowledge Representation Framework for the Statistical Validation of Quantitative Imaging Biomarkers. Journal of Digital Imaging, March 2013, (DOI) 10.1007/s10278-013-9598-3.

    Quantitative Imaging Biomarker Publications

  • Atherosclerotic Drugs, Experimental Biology, Boston, MA, April 2013.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Hamilton JA, Madabhushi A, Keith JC. Non-invasive Theranostic to Predict and Assess Response to Kim HJ, Dima A, Athelogou M, Barnoy E, Lu ZJ, Saiprasad G, Beaumont H, Colditz D, Buckler AJ. Pilot Study for the Comparative Evaluation of Multiple Methods in Estimating Inter- and Intra-method Variability on Nodules from CT Scans of Anthropomorphic Thorax Phantoms. American Thoracic Society May 2013.

    Quantitative Imaging Biomarker Publications

  • Zhao B, Lee S, Lee H. -J, Qi J, Persigehl T, Tan Y, Mozley PD, Buckler AJ, Sullivan D, Schwartz L. Inter-reader and intra-reader variability in assessing change of total tumor volume. IJCARS Conference, June 2013.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Liu TT, Savig E, Suzek BE, Rubin DL, Paik DS. Quantitative Imaging Biomarker Ontology (QIBO) for Knowledge Representation of Biomedical Imaging Biomarkers. Journal of Digital Imaging, 2013; 26(4):630-41.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Paik DS, Ouellette M, Danagoulian J, Wernsing G, Suzek BE. A Novel Knowledge Representation Framework for the Statistical Validation of Quantitative Imaging Biomarkers. Journal of Digital Imaging, 2013; 26(4):614-29.

    Quantitative Imaging Biomarker Publications

  • Narula, J., et al., Histopathologic characteristics of atherosclerotic
    coronary disease and implications of the findings for the invasive and
    noninvasive detection of vulnerable plaques.
     Journal of the American
    College of Cardiology, 2013. 61(10): p. 1041-1051.

    Selected Biophysics Publications

  • Phinikaridou, Alkystis, Giordano, Nicholas and Hamilton, JA. Detection of Thrombus Size and Protein Content by ex vivo Magnetization Transfer and Diffusion Weighted MRI Journal of Cardiovascular Magnetic Resonance, 2012 Jun 25;14(1):45.

    Selected Biophysics Publications

  • Hayash C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, LaValley M, Gibson III FC, Chen Y, Ning H, Hamilton JA, Genco CA.Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol. 2012 Oct 1;189 (7):3681-8.

    Selected Biophysics Publications

  • Kode K, Shachaf C, Elchuri S, Nolan G, Paik DS.Raman Labeled Nanoparticles: Characterization of Variability and Improved Method for Unmixing. Journal of Raman Spectroscopy, 2012; 43(7):895-905.

    Selected Image Processing Publications and Patents

  • Mozley PD, Bendtsen C, Zhao B, Schwartz LH, Thorn M, Rong Y, Zhang L, Perrone A, Korn R, Buckler AJ, Measurement of Tumor Volumes Improves RECIST-based Response Assessments in Advanced Lung Cancer, Transl Oncol. 2012 February; 5(1): 19–25.

    Selected Biophysics Publications

  • Freimuth RF, Freund ET, Schick L, Sharma M, Stafford G, Suzek B, Hernandez J, Hipp J, Kelley J, Rokicki K, Pan S, Buckler AJ, Stokes T, Fernandez A, Fore I, Klemm J, Life sciences domain analysis model. J Am Med Inform Assoc, 2012. 19(6): p. 1095-102.

    Quantitative Imaging Biomarker Publications

  • Lu ZJ, Fenimore C, Petrick N, Zeng R, Gavrielides M, Clunie D, Borradaile K, Ford R, Kim G, McNitt-Gray M, Zhao B, Buckler AJ, Statistical Analysis of Reader Measurement Variability in Nodule Sizing with CT Phantom Imaging Data. NISTIR 7879, November 2012, http://dx.doi.org/10.6028/NIST.IR.7879.

    Quantitative Imaging Biomarker Publications

  • Fenimore C, Lu ZJ, McNitt-Gray MF, Kim HJ, Clunie D, Gavrielides MA, Petrick N, Samei E, Chen B, Saiprasad G, Boedeker K, Chen-Mayer H, Buckler AJ, Clinician sizing of synthetic nodules to evaluate CT interscanner effects. RSNA 2012.

    Quantitative Imaging Biomarker Publications

  • Mozley PD, Bendtsen C, Zhao B, Schwartz LH, Thorn M, Rong Y, Zhang L, Perrone A, Korn R, Buckler AJ, Measurement of Tumor Volumes Improves RECIST-based Response Assessments in Advanced Lung Cancer, Translational Oncology, 2012.

    Quantitative Imaging Biomarker Publications

  • Freimuth RF, Freund ET, Schick L, Sharma M, Stafford G, Suzek B, Hernandez J, Hipp J, Kelley J, Rokicki K, Pan S, Buckler AJ, Stokes T, Fernandez A, Fore I, Klemm J, Life Sciences Domain Analysis Model (LS DAM): A foundational analysis model to support effective information exchange in Life Sciences. J Am Med Inform Assoc (2012). doi:10.1136/amiajnl-2011-000763.

    Quantitative Imaging Biomarker Publications

  • Fenimore C, Lu ZJ, McNitt-Gray MF, Kim HJ, Clunie D, Gavrielides MA, Petrick N, Samei E, Chen B, Saiprasad G, Boedeker K, Chen-Mayer H, Buckler AJ, Clinician sizing of synthetic nodules to evaluate CT interscanner effects. RSNA 2012.

    Quantitative Imaging Biomarker Publications

  • Selected Image Processing Publications and Patents

  • Agner S., X.J., Madabhushi A., A Spectral Embedding based Active Contour (SEAC): Applications to DCE MRIin SPIE Medical Imaging 2011.

    Selected Image Processing Publications and Patents

  • {Tran PT, Bendapudi PK, Lin HJ}, Choi P, Koh S, Chen J, Horng G, Hughes NP, Schwartz LH, Miller VA, Kawashima T, Kitamura T, {Paik D, Felsher DW}. Survival and death signals can predict tumor response to therapy after oncogene inactivation. Science Translational Medicine 2011; 3(103):103ra99. { } = co-equal authorship

    Selected Image Processing Publications and Patents

  • Thomas DG, Klaessig F, Harper SL, Fritts M, Hoover MD, Gaheen S, Stokes TH, Reznik-Zellen R, Freund ET, Klemm JD, Paik DS, Baker NA. Informatics and standards for nanomedicine technology. WIRES Nanomedicine and Nanobiotechnology, 2011; 3(5):511-32.

    Selected Image Processing Publications and Patents

  • Buckler AJ, Boellaard R, Standardization of quantitative imaging: the time is right, and FDG-PET/CT is a good place to start, invited by JNM, volume 52, number 2, February 2011.

    Quantitative Imaging Biomarker Publications

  • Petrick NP, Kim HJ, Clunie D, Borradaile K, Ford R, Zeng R, Gavrieldes MA, McNitt-Gray MF, Fenimore C, Lu J, Zhao B, Buckler AJ. Evaluation of 1D, 2D and 3D nodule size estimation by radiologists for spherical and non-spherical nodules through CT thoracic phantom imaging, SPIE, February 2011.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Kelloff G, Mozley PD, Frank R, et al.,Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities. Radiology, 2011. 259(3): p. 875-84.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Dunnick R, Sullivan D, et al., A collaborative enterprise for multi-stakeholder participation in the advancement of quantitative imaging. Radiology, 2011. 258(3): p. 906-14

    Quantitative Imaging Biomarker Publications

  • McNitt-Gray MF, Kim HJ, Zhao B, Schwartz L, Clunie D, Borradaile K, Byrne K, Kaplan S, Barudin J, Sherman J, Slazak K, Petrick NP, Fenimore C, Lu J, Buckler, AJ, Estimating the Minimum Detectable Change of Lung Lesions Using Patient Datasets Acquired Under a “No Change” Condition, RSNA 2011.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Kelloff G, Mozley PD, Frank R, et al.,Quantitative Imaging Test Approval and Biomarker Qualification: Inter-related but Distinct Activities, Radiology 100800; Published online February 15, 2011, doi:10.1148/radiol.10100800.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Dunnick R, Sullivan D, et al., A Collaborative Enterprise for Multi-Stakeholder Participation in the Advancement of Quantitative Imaging, Radiology: Volume 258(3)-March 2011.

    Quantitative Imaging Biomarker Publications

  • Phinikaridou A, Ruberg FL, Hallock KJ, Qiao Y, Hua N, Viereck JC, Hamilton JA. In vivo Detection of Vulnerable Atherosclerotic Plaque by Magnetic Resonance Imaging in a Rabbit Model. Circ Cardiovasc Imaging, 2010. 3(3): p. 323-32.

    Selected Biophysics Publications

  • Christaki E, Opal SM, Keith Jr JC, Kessinian N , Palardy JE, Parejo NA, Lavallie E, Racie L, Mounts W, Malamas MS, Harris HA, Vlasuk GP. Estrogen Receptor beta (ERb) Agonism Increases Survival in Experimentally Induced Sepsis and ameliorates the genomic sepsis signature: A pharmacogenomic study. J Inf Dis 2010;201(8):1250-57.

    Selected Biophysics Publications

  • Huang A, Moretto A, Janz K, Lowe M, Bedard PW, Tam S, Clerin V, Sushkova N, Tchernychev B, Tsao DHH, Keith Jr JC, Shaw GD, Schaub RG, Vlasuk GP, Wang Q, Kaila N. Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl) quinoline-4-carboxylic acid (PSI-421) a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury J Med Chem 2010;53(16):6003-17.

    Selected Biophysics Publications

  • Hayashi C, Viereck J, Hua N, Phinikaridou A, Madrigal AG, Gibson FC 3rd, Hamilton JA, Genco CA Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice.Atherosclerosis. 2010 Dec 22.

    Selected Biophysics Publications

  • Rachel Sparks and Anant Madabhushi, Novel Morphometric Based Classification via Diffeomorphic Based Shape Representation Using Manifold Learning. MICCAI 2010, Part III, LNCS 6363, pp. 658–665, 2010.

    Selected Image Processing Publications and Patents

  • Selected Image Processing Publications and Patents

  • Roos JE, Paik DS, Olsen D, Liu EG, Chow LC, Leung AN, Mindelzun R, Naidich DP, Napel S, Rubin GD. Computer-aided detection (CAD) of lung nodules on CT: Radiologist performance and reading time with incremental CAD assistance. European Radiology, 2010; 20(3):549-57.

    Quantitative Imaging Biomarker Publications

  • Choudhury KR, Paik DS, Yi CA, Napel S, Roos JE, Rubin GD. Assessing Operating Characteristics of CAD Algorithms in the Absence of a Gold Standard. Medical Physics, 2010; 37(4):1788-95.

    Selected Image Processing Publications and Patents

  • Pu J, Paik DS, Meng X, Roos JE, Rubin GD. Shape Break-and-Repair Strategy and Its Application to Automated Medical Image Segmentation.  IEEE Transactions on Visualization and Computer Graphics, 2010; 17(1):115-24.

    Selected Image Processing Publications and Patents

  • Buckler AJ, Mulshine JL, Gottlieb R, Zhao B, Mozley PD, Schwartz L. The use of volumetric CT as an imaging biomarker in lung cancer. Academic radiology, 2010. 17(1): p. 100-6.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Mozley PD, Schwartz LH, Petrick N, McNitt-Gray M, Fenimore C, O’Donnell K, Hayes W, Kim HJ, Clarke L, Sullivan DC. Volumetric CT in lung cancer: an example for the qualification of imaging as a biomarker. Academic radiology, 2010. 17(1): p. 107-15.

    Quantitative Imaging Biomarker Publications

  • Mozley PD, Buckler AJ, et al., Change in lung tumor volume as a biomarker of treatment response: a critical review of the evidence. Ann Oncol, 2010. 21(9): p. 1751-5.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Schwartz LH, Petrick N, McNitt-Gray M, Zhao B, Fenimore C, Reeves AP, Mozley PD, Avila RS. Data Sets for the Qualification of CT as a Quantitative Imaging Biomarker in Lung Cancer. Optics express, 2010. 18(14): p. 16.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, The Emerging Role of Quantitative Imaging, Next Generation Pharmaceutical, Issue 19, June 2010.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Mozley PD, Schwartz LH, Petrick N, McNitt-Gray M, Fenimore C, O’Donnell K, Hayes W, Kim HJ, Clarke L, Sullivan DC. Volumetric CT in Lung Cancer: An Example for the Qualification of Imaging as a Biomarker, Academic Radiology, Vol 17, No 1, January 2010, 107-115.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Next Generation Pharmaceutical, Issue 19, June 2010. Next Generation Pharmaceutical, Issue 19, June 2010.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Mozley PD, Schwartz LH, Petrick N, McNitt-Gray M, Fenimore C, O’Donnell K, Hayes W, Kim HJ, Clarke L, Sullivan DC. Volumetric CT in lung cancer: an example for the qualification of imaging as a biomarker. Academic radiology, 2010. 17(1): p. 107-15.

    Quantitative Imaging Biomarker Publications

  • Buckler AJ, Mulshine JL, Gottlieb R, Zhao B, Mozley PD, Schwartz L. The use of volumetric CT as an imaging biomarker in lung cancer. Academic radiology, 2010. 17(1): p. 100-6.

    Quantitative Imaging Biomarker Publications

  • Phinikaridou A, Hallock KJ, Qiao Y, Hamilton JA. A robust rabbit model of human atherosclerosis and atherothrombosis. J Lipid Res. 2009; 50:787-797.

    Selected Biophysics Publications

  • Quinet EM, Basso MD, Halperin AR, Yates DW, Steffan RJ, Clerin V, Remini C, Keith JC, Berrodin TJ, Feingold I, Zhong W, Hartman HB, Evans MJ, Gardell SJ, DiBlasio-Smith E, Mounts WM, Lavallie ER, Wrobel J, Nambi P, Vlasuk GP. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J Lipid Res 2009; 50(12):2358-70.March 24.

    Selected Biophysics Publications

  • Quinet EM, Basso MD, Halperin AR, Yates DW, Steffan RJ, Clerin V, Remini C, Keith JC, Berrodin TJ, Feingold I, Zhong W, Hartman HB, Evans MJ, Gardell SJ, DiBlasio-Smith E, Mounts WM, Lavallie ER, Wrobel J, Nambi P, Vlasuk GP. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J Lipid Res 2009; 50(12):2358-70.March 24.

    Selected Biophysics Publications

  • Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009 Mar 24;119(11):1501-9. Epub 2009 Mar. PMID: 9273719

    Selected Biophysics Publications

  • Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W. Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes. 2009 Aug;58(8):1739-48. Epub 2009 Jun 9.PMID: 19509018

    Selected Biophysics Publications

  • Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W. Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes. 2009 Aug;58(8):1739-48. Epub 2009 Jun 9.PMID: 19509018

    Selected Biophysics Publications

  • Ruberg FL, Chen Z, Hua N, Bigornia S, Guo Z, Hallock K, Jara H, LaValley M, Phinikaridou A, Qiao Y, Viereck J, Apovian CM, Hamilton JA. The relationship of ectopic lipid accumulation to cardiac and vascular function in obesity and metabolic syndrome. Obesity (Silver Spring). 2010 Jun;18(6):1116-21. Epub 2009 Oct 29.PMID: 19875992.

    Selected Biophysics Publications

  • Yaghoubi SS, Jensen MC, Satyamurthy N, Budhiraja S, Paik DS, Czernin J, Gambhir SS. Noninvasive Detection of Therapeutic Cytolytic T Cells with 18F-FHBG PET in a Patient with Glioma. Nature Clinical Practice Oncology 2009; 6(1):53-8.

    Selected Image Processing Publications and Patents

  • Tiwari, P., Rosen, M, Galen, P, Kurhanewicz, J, Madabhushi, A. Spectral Embedding based Probabilistic boosting Tree (ScEPTre): Classifying High Dimensional Heterogeneous Biomedical Data. in Medical Image Computing and Computer Assisted Intervention. 2009. London, UK: Springer Verlag.

    Selected Image Processing Publications and Patents

  • Selected Image Processing Publications and Patents

  • Selected Image Processing Publications and Patents

  • Selected Image Processing Publications and Patents

  • Buckler AJ, A procedural template for the qualification of imaging as a biomarker, using volumetric CT as an example, in IEEE Applied Imagery Pattern Recognition Workshop 2009: Cosmos Club, Washington, D.C. p. 7.

    Quantitative Imaging Biomarker Publications

  • Lavi, S., et al., Segmental coronary endothelial dysfunction in patients
    with minimal atherosclerosis is associated with necrotic core plaques.

    Heart, 2009. 95(18): p. 1525-1530.

    Selected Biophysics Publications

  • Buckler AJ, A procedural template for the qualification of imaging as a biomarker, using volumetric CT as an example, in IEEE Applied Imagery Pattern Recognition Workshop 2009: Cosmos Club, Washington, D.C. p. 7.

    Quantitative Imaging Biomarker Publications

  • Bedard, PW, Clerin, V, Sushkova, N, Tchernychev B, Antrilli T, Resmini C, Keith, JC Jr. , Hennan JK, Kaila, N, DeBernardo, S, Janz, K, Wnag Q, Crandall DL, Schaub, RG, Shaw, GD, Carter LL.Characterization of the Novel P-Selectin Inhibitor PSI-697 In Vitro in Rodent Models of Vascular Inflammation and thrombosis. JPET 2008;324(2):497-506 EPub November 16, 2007.

    Selected Biophysics Publications

  • Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, Hamilton JA, Ouchi N, LeBrasseur NK, Walsh K. Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab. 2008 Feb;7(2):159-72.

    Selected Biophysics Publications

  • Clerin V, Shih HH, Deng N, Hebert G, Resmini C, Shields KM, Feldman J, Winkler A, Albert L, Maganti V, Paulsen JE, Keith, Jr. JC, Vlasuk GP, Pittman DD. Expression of the Cysteine Protease, Legumain, in Vascular Lesions and Functional Implications in Atherogenesis. Atherosclerosis 2008;201:53-66, E-Pub Feb 21, 2008.

    Selected Biophysics Publications

  • Wang X, Keith, Jr. JC, Struthers AD, and Feuerstein GZ. Assessment of Arterial Stiffness: A translational medicine biomarker system for evaluation of vascular risk. Cardiovasc Ther 2008: 26:214-23.

    Selected Biophysics Publications

  • Qiao Y, Farber A, Semaan E, Hamilton JA; Images in cardiovascular medicine. Healing of an asymptomatic carotid plaque ulceration Circulation, 2008. 118(10): p. e147-8.

    Selected Biophysics Publications

  • Toth, R., Multi-Attribute Non-Intializing Texture Reconstruction Based Active Shape Model (MANTRA). Med Image Comput Comput Assist Interv, 2008. 11(Pt1): p. 653-61.

    Selected Image Processing Publications and Patents

  • Viswanath, S., et al., A comprehensive segmentation, registration, and cancer detection scheme on 3 Tesla in vivo prostate DCE-MRI. Med Image Comput Comput Assist Interv, 2008. 11(Pt 1): p. 662-9.

    Selected Image Processing Publications and Patents

  • Tiwari, P., M. Rosen, and A. Madabhushi, Consensus-locally linear embedding (C-LLE): application to prostate cancer detection on magnetic resonance spectroscopy. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv, 2008. 11(Pt 2): p. 330-8

    Selected Image Processing Publications and Patents

  • Lee, G., C. Rodriguez, and A. Madabhushi, Investigating the efficacy of nonlinear dimensionality reduction schemes in classifying gene and protein expression studies. IEEE/ACM Trans Comput Biol Bioinform, 2008. 5(3): p. 368-84.

    Selected Image Processing Publications and Patents

  • Selected Image Processing Publications and Patents

  • Pu J, Roos J, Yi CA, Napel S, Rubin GD, Paik DS. Adaptive Border Marching Algorithm: Automatic Lung Segmentation on Chest CT Images. Computerized Medical Imaging and Graphics2008; 32:452-62.

    Selected Image Processing Publications and Patents

  • Lavi, S., et al., The interaction between coronary endothelial
    dysfunction, local oxidative stress, and endogenous nitric oxide in humans.

    Hypertension, 2008. 51(1): p. 127-133.

    Selected Biophysics Publications

  • O. Ziouzenkova, G. O. M. Sharlach, T. E. Akiyama, J. P. Berger, J. Viereck, J. A. Hamilton, G. Tang, G. G. Dolnikowski & Jorge Plutzky. Retinaldehyde inhibits adipogenesis and regulates activation of RXR heterodimers. Nat Med 2007. (6):695-702. Epub 2007 May 27.

    Selected Biophysics Publications

  • Hamilton J.A. and Deckelbaum R. D. The crystal structure of CETP: new hope for raising HDL to decrease risk if cardiovascular disease? Nature Structural and Molecular Biology. 2007 Feb;14 (2):95-7.

    Selected Biophysics Publications

  • Qiao Y, Ronen I, Viereck J, Ruberg F, Hamilton JA; Identification of atherosclerotic lipid deposits by diffusion-weighted imaging. Arterioscler Thromb Vasc Biol, 2007. 27(6): p. 1440-6.

    Selected Biophysics Publications

  • Hu B, Jetter J, Kaufman D, Singhaus R,Bernotas R, Unwalla R Quinet E, Savio D, Halpern A, Basso M, Keith J, Clerin V, Chen L, Liu Q-Y, Feingold I, Huselton C, Azam F, Goos-Nilsson A, Wilhelmsson A, Nambi P, Wrobel J. Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorganic Medicinal Chem 2007;15:3321-33.

    Selected Biophysics Publications

  • Lutterloh E, Opal SM, Pittman DD, Keith Jr JC, Tan X-Y, Clancy BM, Palmer H, Milarski K, Palardy JE, Parejo NA, Kessimian N. Inhibition of the receptor for advanced glycation end products(RAGE) provides significant survival advantage in experimental models of systemic infection and severe sepsis. Critical Care 2007;11(6):R122. Epub November 27, 2007.

    Selected Biophysics Publications

  • Sun S, Rubin GD, Paik DS, Steiner RM, Zhuge F, Napel S. Registration of Lung Nodules Using a Semi-rigid Model: Method and Preliminary Result. Medical Physics 2007; 34(2):613-26.

    Selected Image Processing Publications and Patents

  • Chappelow, J., Madabhushi, A, Rosen, M, Tomaszeweski, J, Feldman, M, Multimodal Image Registration of ex vivo 4 Tesla Prostate MRI with Whole Mount Histology for Cancer Detection, in SPIE Medical Imaging 2007: San Diego, CA. p. p. S1-S12.

    Selected Image Processing Publications and Patents

  • Tiwari, P., A. Madabhushi, and M. Rosen, A hierarchical unsupervised spectral clustering scheme for detection of prostate cancer from magnetic resonance spectroscopy (MRS). Med Image Comput Comput Assist Interv, 2007. 10(Pt 2): p. 278-86.

    Selected Image Processing Publications and Patents

  • Konukoglu E, Acar B, Paik DS, Beauleu CF, Napel S. PELS: Polyp Enhancing Level-Set Evolution of the Colon Wall. IEEE Transactions on Medical Imaging 2007; 26(12):1649-56.

    Selected Image Processing Publications and Patents

  • Ruberg F, Viereck J, Phinikaridou A, Qiao Y, Loscalzo J, Hamilton JA, Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS. J Lipid Res, 2006. 47(2): p. 310-7.

    Selected Biophysics Publications

  • Cristofaro P, Opal SM, Palardy JE, Parejo N, Jhung J, Keith Jr JC, Harris HA. WAY- 202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Critical Care Med 2006; 34:2188-93, E-pub May 30,2006.

    Selected Biophysics Publications

  • Doyle, S., Madabhushi, A., Feldman, M., Tomaszeweski, J, A Boosting Cascade for Automated Detection of Prostate Cancer from Digitized Histology, in Medical Image Computing and Computer Assisted Intervention 2006, Springer Verlag: Copenhagen, Denmark. p. 504-511.

    Selected Image Processing Publications and Patents

  • Pineda AR, Yoon S, Paik DS, Fahrig R.Optimization of a Tomosynthesis System for the Detection of Lung Nodules. Medical Physics 2006; 33(5): 1372-79.

    Selected Image Processing Publications and Patents

  • Madabhushi, A., Shi, J, Rosen, M, Tomaszeweski, J, Feldman, M, Comparing Classification Performance of Feature Ensembles: Detecting Prostate Cancer from High Resolution MRI, in Computer Vision Methods in Medical Image Analysis (In conjunction with ECCV) 2006, Springer Verlag. p. 25-36.

    Selected Image Processing Publications and Patents

  • Viereck J, Ruberg FL, Qiao Y, Perez AS, Detwiller K, Johnstone M, Hamilton JA; MRI of atherothrombosis associated with plaque rupture. Arteriosclerosis Thrombosis And Vascular Biology, 2005. 25(1): p. 240-245.

    Selected Biophysics Publications

  • Rubin GD, Lyo J, Paik DS, Sherbondy A, Chow L, Leung AN, Mindelzun R, Zinck SE, Naidich DP, Napel S. Pulmonary Nodules in MDCT Scans: Impact of Computer-Aided Detection. Radiology 2005; 235(1):274-83.

    Selected Image Processing Publications and Patents

  • Madabhushi, A., et al., Graph embedding to improve supervised classification and novel class detection: application to prostate cancer. Med Image Comput Comput Assist Interv, 2005. 8(Pt 1): p. 729-37.

    Selected Image Processing Publications and Patents

  • Johnstone, M. T, Perez, A. S., Nasser, I., Stewart, R., Al Ammary, F., Schmidt, B., Horowitz, G, Hamilton, J. A, and W. C. Quist. Angiotensin Receptor Blockade with Candesartan Attenuates Atherosclerosis, Plaque Disruption and Macrophage Accumulation in a Rabbit Model. Circulation, 2004;110:2060-2065.

    Selected Biophysics Publications

  • Botnar RM, Perez AS, Witte S, Wiethoff AJ, Laredo J, Hamilton JA, Quist W, Parsons EC, Jr., Vaidya A, Kolodziej A, Barrett JA, Graham PB, Weisskoff RM, Manning WJ, Johnstone MT. In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent. Circulation. 2004;109:2023-2029.

    Selected Biophysics Publications

  • Mani A, Napel S, Paik DS, Jeffrey RB, Yee J, Olcott EW, Prokesch R, Davila M, Schraedley-Desmond P, Beaulieu CF. CT Colonography: Feasability of Computer-Aided Polyp Detection in a First Reader Paradigm. Journal of Computer Assisted Tomography 2004; 28(3):318-26.

    Selected Image Processing Publications and Patents

  • Paik DS, Beaulieu CF, Rubin GD, Acar B, Jeffrey RB, Yee J, Dey J, Napel S. Surface Normal Overlap: A Computer-Aided Detection Algorithm with Application to Colonic Polyps and Lung Nodules in Helical CT. IEEE Transactions on Medical Imaging 2004; 23(6):661-75.

    Selected Image Processing Publications and Patents

  • Li P, Napel S, Acar B, Paik DS, Jeffrey RB, Beaulieu CF. Automatic Registration of Colonic Polyps Between Supine and Prone Scans in CT Colonography. Medical Physics 2004; 31(10):2912-23.

    Selected Image Processing Publications and Patents

  • Madabhushi, A., Feldman, M, Metaxas, D, Chute, D, Tomaszeweski, J, Optimally Combining 3D Texture Features for Automated Segmentation of Prostatic Adenocarcinoma from High Resolution MR Images, in IEEE International Conference of Engineering in Medicine and Biology Society 2003: Cancun, Mexico. p. 614-17.

    Selected Image Processing Publications and Patents

  • Sundaram P, Beaulieu CF, Paik DS, Schraedley-Desmond P, Napel S. CT Colonography: Does improved z resolution help computer-aided polyp detection? Medical Physics 2003; 30(10):2663-74.

    Selected Image Processing Publications and Patents

  • Napel S, Xu H, Paik DS, Ross BA, Sumanaweera TS, Hossack J, Jeffrey RB. Carotid Disease: Automated Analysis with Cardiac-gated Three-dimensional US Technique and Preliminary Results. Radiology 2002; 222(2): 560-3.

    Selected Biophysics Publications

  • Hung PW, Paik DS, Napel S, Yee J, Steinauer-Gebauer A, Jeffrey RB, Min J, Jathavedam A, Beaulieu CF. Quantification of Distension in CT Colonography: Development and Validation of Three Computer Algorithms. Radiology 2002; 222(2): 543-54.

    Selected Image Processing Publications and Patents

  • Acar B, Beaulieu CF, Gokturk SB, Tomasi C, Paik DS, Jeffrey RB, Yee J, Napel S. Edge Displacement Field Based-Classification for Improved Detection of Polyps in CT Colonography. IEEE Transactions on Medical Imaging 2002; 21(12): 1461-67.

    Selected Image Processing Publications and Patents

  • Johnstone MT, Botnar RM, Perez AS, Stewart R, Quist WC, Hamilton JA, Manning WJ. In vivo magnetic resonance imaging of experimental thrombosis in a rabbit model. Arterioscler Thromb Vasc Biol. 2001;21:1556-1560

    Selected Biophysics Publications

  • Lee X, Keith Jr JC, McCoy JM, Crum CP, Genest D, Chin D, Pijnenborg R, Van Assche FA, Mi S. Down-Regulation of placental syncytin expression and abnormal protein localization in preeclampsia. Placenta, 22(10):808-12, 2001.

    Selected Biophysics Publications

  • Gokturk SB, Tomasi C, Acar B, Beaulieu CF, Paik DS, Jeffrey RB, Yee J, Napel S. A Statistical 3D Pattern Processing Method for Computer Aided Detection of Polyps in CT Colonography. IEEE Transactions on Medical Imaging 2001; 20(12): 1251-60.

    Selected Image Processing Publications and Patents

  • Gokturk SB, Tomasi C, Acar B, Beaulieu CF, Paik DS, Jeffrey RB, Yee J, Napel S. A Statistical 3D Pattern Processing Method for Computer Aided Detection of Polyps in CT Colonography. IEEE Transactions on Medical Imaging 2001; 20(12): 1251-60.

    Selected Image Processing Publications and Patents

  • Keith, Jr JC, Pijnenborg R, Luyten C, Spitz B, Schaub R,, Van Assche FA. Maternal serum levels of macrophage colony stimulating factor are related to adverse pregnancy outcome. Eur J Obstet Gynecol 2000;89:19-25.

    Selected Biophysics Publications

  • Mi S, Lee X, Veldman GM, Finnerty H, Racie L, LaVallie E, Edouard P, Howes S, Keith J, McCoy JM. Syncytin, a captured retroviral envelope protein involved in human placental morphogenesis. Nature 2000; 403:785-789.

    Selected Biophysics Publications

  • Kumar A, Villani MP, Patel UK, Keith, Jr JC, Schaub RG. Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model. Circulation 1999;99:1363-1369.

    Selected Biophysics Publications

  • Pijnenborg R. McLaughlin PJ, Vercruysse L, Hanssens M, Johnson PM, Keith, Jr JC, Van Assche FA. Immunolocalization of tumor necrosis factor-a (TNF-a) in the placental bed of normotensive and hypertensive human pregnancies. Placenta 1998;19:231-239.

    Selected Biophysics Publications

  • Spitz B, Witters K, Hanssens M, Van Assche FA, Keith, Jr JC. Ketanserin, a 5-HT2 serotonergic receptor antagonist, could be useful in the HELLP syndrome. Hypertension in Pregnancy 1993; 12:183-190.

    Selected Biophysics Publications

  • Selected Biophysics Publications

  • Smucker ML, Kaul S, Woodfield JA, Keith, Jr, JC, Manning SA, Gascho JA: Naturally occurring cardiomyopathy in the Doberman Pinscher: A model of human cardiomyopathy? J Am Coll Cardiol 1990;16:200-206.

    Selected Biophysics Publications

  • Keith, Jr. JC, Miller KW, Eggleston MK, Kutruff J, Howerton T, Konczal C, McDaniels C. Effects of thromboxane synthetase inhibition on maternal/fetal homeostasis in gravid ewes with ovine pregnancy-induced hypertension. Am J Obstet Gynecol 161:1305-13,1989.

    Selected Biophysics Publications

  • Glagov, S., et al., Compensatory enlargement of human atherosclerotic
    coronary arteries.
     N Engl J Med, 1987. 316(22): p. 1371-5.

    Selected Biophysics Publications

  • Selected Biophysics Publications

  • Selected Biophysics Publications

  • Selected Biophysics Publications

  • Lavi, S., et al., Local production of lipoprotein-associated phospholipase
    A2 and lysophosphatidylcholine in the coronary circulation: association
    with early coronary atherosclerosis and endothelial dysfunction in humans.

    Circulation, 2007. 115(21): p. 2715-2721.

    Selected Biophysics Publications