Refereed Journal Papers


  1. Habte F, Ren G, Doyle TC, Liu H, Cheng Z, Paik DS, "Impact of a Multiple Mice Holder on Quantitation of High-Throughput microPET Imaging with and without CT Attenuation Correction," Journal of Molecular Imaging and Biology, 2013; 15(5):569-75.
  2. Buckler AJ, Liu TT, Savig E, Suzek BE, Rubin DL, Paik DS, "Quantitative Imaging Biomarker Ontology (QIBO) for Knowledge Representation of Biomedical Imaging Biomarkers," Journal of Digital Imaging, 2013; 26(4):630-41. (see erratum)
  3. Buckler AJ, Paik DS, Ouellette M, Danagoulian J, Wernsing G, Suzek BE, "A Novel Knowledge Representation Framework for the Statistical Validation of Quantitative Imaging Biomarkers," Journal of Digital Imaging, 2013; 26(4):614-29.
  4. Habte F, Budhiraja S, Keren S, Doyle TC, Levin CS, Paik DS, "In situ Study of the Impact of Inter- and Intra-reader Variability on Region of Interest (ROI) Analysis in Preclinical Molecular Imaging," American Journal of Nuclear Medicine and Molecular Imaging, 2013; 3(2):175-181.
  5. Nwabugwu C, Rakhra K, Felsher DW, Paik DS, "In Vivo Imaging-based Mathematical Modeling Techniques that Enhance the Understanding of Oncogene Addiction in Relation to Tumor Growth," Computational and Mathematical Methods in Medicine, 2013; 2013(802512):1-8.
  6. Thomas DG, Gaheen S, Harper SL, Fritts M, Klaessig F, Hahn-Dantona E, Paik DS, Pan S, Stafford G, Freund ET, Klemm J, Baker NA, "ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format," BMC Biotechnology, 2013; 13:2.
  7. Kode K, Shachaf C, Elchuri S, Nolan G, Paik DS, "Raman Labeled Nanoparticles: Characterization of Variability and Improved Method for Unmixing," Journal of Raman Spectroscopy, 2012; 43(7):895-905.
  8. {Tran PT, Bendapudi PK, Lin HJ}, Choi P, Koh S, Chen J, Horng G, Hughes NP, Schwartz LH, Miller VA, Kawashima T, Kitamura T, {Paik D, Felsher DW}, "Survival and death signals can predict tumor response to therapy after oncogene inactivation," Science Translational Medicine 2011; 3(103):103ra99. { } = co-equal authorship.
  9. Thomas DG, Klaessig F, Harper SL, Fritts M, Hoover MD, Gaheen S, Stokes TH, Reznik-Zellen R, Freund ET, Klemm JD, Paik DS, Baker NA, "Informatics and standards for nanomedicine technology," WIRES Nanomedicine and Nanobiotechnology, 2011; 3(5):511-32.
  10. Pu J, Paik DS, Meng X, Roos JE, Rubin GD, "Shape Break-and-Repair Strategy and Its Application to Automated Medical Image Segmentation," IEEE Transactions on Visualization and Computer Graphics, 2010; 17(1):115-24.
  11. Choudhury KR, Paik DS, Yi CA, Napel S, Roos JE, Rubin GD, "Assessing Operating Characteristics of CAD Algorithms in the Absence of a Gold Standard," Medical Physics, 2010; 37(4):1788-95.
  12. Roos JE, Paik DS, Olsen D, Liu EG, Chow LC, Leung AN, Mindelzun R, Naidich DP, Napel S, Rubin GD, "Computer-aided detection (CAD) of lung nodules on CT: Radiologist performance and reading time with incremental CAD assistance," European Radiology, 2010; 20(3):549-57.
  13. Yaghoubi SS, Jensen MC, Satyamurthy N, Budhiraja S, Paik DS, Czernin J, Gambhir SS, "Noninvasive Detection of Therapeutic Cytolytic T Cells with 18F-FHBG PET in a Patient with Glioma," Nature Clinical Practice Oncology 2009; 6(1):53-8.
  14. Pu J, Roos J, Yi CA, Napel S, Rubin GD, Paik DS, "Adaptive Border Marching Algorithm: Automatic Lung Segmentation on Chest CT Images," Computerized Medical Imaging and Graphics2008; 32:452-62.
  15. Konukoglu E, Acar B, Paik DS, Beauleu CF, Napel S. "PELS: Polyp Enhancing Level-Set Evolution of the Colon Wall," IEEE Transactions on Medical Imaging 2007; 26(12):1649-56.
  16. Sun S, Rubin GD, Paik DS, Steiner RM, Zhuge F, Napel S. "Registration of Lung Nodules Using a Semi-rigid Model: Method and Preliminary Results," Medical Physics 2007; 34(2):613-26.
  17. Shi R, Schraedley-Desmond P, Napel S, Olcott EW, Jeffrey RB, Yee J, Zalis ME, Margolis D, Paik DS, Sherbondy AJ, Sundaram P, Beaulieu CF. "CT Colonography: Influence of 3D Viewing and Features of Polyp Candidates on Interpretation using Computer Aided Detection." Radiology 2006: 239 768-776.
  18. Pineda AR, Yoon S, Paik DS, Fahrig R. "Optimization of a Tomosynthesis System for the Detection of Lung Nodules." Medical Physics 2006; 33(5): 1372-79.
  19. Rubin GD, Lyo J, Paik DS, Sherbondy A, Chow L, Leung AN, Mindelzun R, Zinck SE, Naidich DP, Napel S. "Pulmonary Nodules in MDCT Scans: Imapct of Computer-Aided Detection." Radiology 2005; 235(1):274-83.
  20. Li P, Napel S, Acar B, Paik DS, Jeffrey RB, Beaulieu CF. "Automatic Registration of Colonic Polyps Between Supine and Prone Scans in CT Colonography." Medical Physics 2004; 31(10):2912-23.
  21. Paik DS, Beaulieu CF, Rubin GD, Acar B, Jeffrey RB, Yee J, Dey J, Napel S. "Surface Normal Overlap: A Computer-Aided Detection Algorithm with Application to Colonic Polyps and Lung Nodules in Helical CT." IEEE Transactions on Medical Imaging 2004; 23(6):661-75.
  22. Mani A, Napel S, Paik DS, Jeffrey RB, Yee J, Olcott EW, Prokesch R, Davila M, Schraedley-Desmond P, Beaulieu CF. "CT Colonography: Feasability of Computer-Aided Polyp Detection in a First Reader Paradigm." Journal of Computer Assisted Tomography 2004; 28(3):318-26.
  23. Sundaram P, Beaulieu CF, Paik DS, Schraedley-Desmond P, Napel S. "CT Colonography: Does improved z resolution help computer-aided polyp detection?" Medical Physics 2003; 30(10):2663-74.
  24. Acar B, Beaulieu CF, Gokturk SB, Tomasi C, Paik DS, Jeffrey RB, Yee J, Napel S. "Edge Displacement Field Based-Classification for Improved Detection of Polyps in CT Colonography." IEEE Transactions on Medical Imaging 2002; 21(12): 1461-67.
  25. Hung PW, Paik DS, Napel S, Yee J, Steinauer-Gebauer A, Jeffrey RB, Min J, Jathavedam A, Beaulieu CF. "Quantification of Distension in CT Colonography: Development and Validation of Three Computer Algorithms." Radiology 2002; 222(2): 543-54.
  26. Napel S, Xu H, Paik DS, Ross BA, Sumanaweera TS, Hossack J, Jeffrey RB. "Carotid Disease: Automated Analysis with Cardiac-gated Three-dimensional US Technique and Preliminary Results." Radiology 2002; 222(2): 560-3.
  27. Gokturk SB, Tomasi C, Acar B, Beaulieu CF, Paik DS, Jeffrey RB, Yee J, Napel S. "A Statistical 3D Pattern Processing Method for Computer Aided Detection of Polyps in CT Colonography." IEEE Transactions on Medical Imaging 2001; 20(12): 1251-60.
  28. Tillich M, Hill BB, Paik DS, Petz K, Napel S, Zarins CK, Rubin GD. "Prediction of Aortoiliac Stent-Graft Length: Comparison of Measurement Methods." Radiology 2001; 220(2): 475-83.
  29. Tillich M, Bell RE, Paik DS, Fleischmann D, Sofilos MC, Logan LJ, Rubin GD. "Iliac Arterial Injuries after Endovascular Repair of Abdominal Aortic Aneurysms: Correlation with Iliac Curvature and Diameter." Radiology 2001; 219(1): 129-36.
  30. Fleischmann D, Hastie TJ, Dannegger FC, Paik DS, Tillich M, Zarins CK, Rubin GD. "Quantitative Determination of Age-related Geometric Changes in the Abdominal Aorta." Journal of Vascular Surgery 2001; 33(1): 97-105.
  31. Fleischmann D, Rubin GD, Paik DS, Yen SY, Hilfiker P, Beaulieu CF, Napel S. "Stair-Step Artifacts with Single versus Multiple Detector-Row Helical CT." Radiology 2000; 216(1): 185-96.
  32. Paik DS, Beaulieu CF, Jeffrey RB, Karadi CA, Napel S. "Visualization Modes for CT Colonography using Cylindrical and Planar Map Projections." Journal of Computer Assisted Tomography 2000; 24(2): 179-88.
  33. Karadi CA, Beaulieu CF, Jeffrey RB, Paik DS, Napel S. "Display Modes for CT Colonography. Part I: Synthesis and Insertion of Polyps into Patient CT Data." Radiology 1999; 212(1):195-201.
  34. Beaulieu CF, Jeffrey RB, Karadi CA, Paik DS, Napel S. "Display Modes for CT Colonography. Part II: Blinded Comparison of Axial CT and Virtual Endoscopic and Panoramic Endoscopic Volume Rendered Studies." Radiology 1999; 212(1): 203-12.
  35. Alley MT, Napel S, Amano Y, Paik DS, Shifrin RY, Shimakawa A, Pelc NJ, Herfkens RJ. "Fast 3D Cardiac Cine MR Imaging." Journal of Magnetic Resonance Imaging 1999; 9(5): 751-755.
  36. Sheikh SF, Paik DS, Beaulieu CF, Rubin GD, Jeffrey RB, Napel S. "Wide-Angle Virtual Endoscopy using Multiple-View Rendering: The Virtual Cockpit." RSNA EJ 1998; 2.
  37. Paik DS, Beaulieu CF, Jeffrey RB, Rubin GD, Napel S. "Automated flight path planning for virtual endoscopy." Medical Physics 1998; 25(5):629-637.
  38. Rubin GD, Paik DS, Johnston PC, Napel S. "Measurement of the aorta and its branches with helical CT." Radiology 1998; 206(3):823-829.

Refereed Conference Proceedings Papers


  1. Habte F, Natarajan A, Doyle TC, Paik DS, Gambhir SS. "A simple model for deep tissue attenuation correction and large organ analysis of Cerenkov luminescence imaging," Proceedings of SPIE Medical Imaging 2014, San Diego, CA, February 2014.
  2. Nwabugwu C, Rakhra K, Felsher DW, Paik DS. "A tumor-immune mathematical model of CD4+ T helper cell dependent tumor regression by inactivation oncogene inactivation," 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Osaka, Japan, July 2013.
  3. {Fan-Minogue H, Maslove D, Lamb P}, Levitt J, {Paik DS, Rubin DL}, "Extracting Computational and Semantic Features from Portable Chest X-rays for Diagnosis of Acute Respiratory Distress Syndrome," AMIA Joint Summits on Translational Science, San Francisco, CA, March 2013. { } = co-equal authorship.
  4. Nwabugwu C, Rakhra K, Felsher DW, Paik DS. "Mathematical Modeling of the Interactions between Cellular Programs in Response to Oncogene Inactivation." Proceedings of 12thInternational Conference on Bioinformatics and Bioengineering (BIBE), Larnaca, Cyprus, November 2012. Second place winner of Student Paper Competition Winner of Stanford University School of Engineering and BioX Travel Awards.
  5. Schmitzberger FF, Roos J, Napel S, Rubin G, Paik DS. "Thin Client Architecture in Support of Remote Radiology Learning." Proceedings of the 24th Annual ACM Symposium on Applied Computing, 842-46, Honolulu, HI, 2009.
  6. Sherman MA, JL Middleton, JP Schmidt, DS Paik, SS Blemker, AW Habib, FC Anderson, SL Delp and RB Altman. "The SimTK Framework for physics-based simulation of biological structures: preliminary design." Proceedings of the Workshop on Component Models and Frameworks in High Performance Computing (CompFrame 2005), Atlanta, GA, June 2005.
  7. Acar B, Napel S, Paik DS, Yee J, Gokturk SB, Tomasi C, Beaulieu CF. "Assessment of Optical Flow Field Based Polyp Detectors for CT Colonography." 23rd International Conference on the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey, October 2001.
  8. Acar B, Napel S, Paik DS, Li P, Yee J, Jeffrey RB, Beaulieu CF. "Medial Axis Registration of Supine and Prone CT Colonography Data." 23rd International Conference on the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey, October 2001.
  9. Gokturk SB, Tomasi C, Acar B, Paik DS, Beaulieu CF, Napel S. "A New 3D Volume Processing Method for Polyp Detection." 23rd International Conference on the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey, October 2001.
  10. Acar B, Napel S, Paik DS, Gokturk SB, Tomasi C, Beaulieu CF. "Using Optical Flow Fields for Polyp Detection in Virtual Colonoscopy." 4th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Utrecht, The Netherlands, October 2001.
  11. Gokturk SB, Tomasi C, Acar B, Paik DS, Beaulieu CF, Napel S. "A Learning Method for Automated Polyp Detection." 4th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI), Utrecht, The Netherlands, October 2001.

David S. Paik, Ph.D.
Director of Imaging Science


Director of Imaging Science, David S. Paik, Ph.D., joins Elucid Bioimaging with 20 years of academic research in biomedical image analysis including 49 journal papers, 99 conference abstracts and several book chapters and patents. His expertise spans medical image analysis, machine learning, scientific visualization, biomedical informatics, biomathematical modeling, cancer nanotechnology, and statistics.

After earning his Ph.D. in Biomedical Informatics at Stanford University, Dr. Paik was an Assistant Professor of Radiology at Stanford for over 8 years where he led a research group focused on methods of image analysis for clinical imaging and molecular imaging and on biomathematical modeling. He currently holds an appointment of Consulting Assistant Professor of Radiology at Stanford. He leads the company’s pioneering efforts on image analysis methods and disease modeling in numerous clinical applications.